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KMID : 0385019920080020255
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Korean Journal of Laboratory Animal Science
1992 Volume.8 No. 2 p.255 ~ p.258
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A Study on the antitumor activity of recombinant human lymphotoxin
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김원용/Kim, Won Yong
최윤호/최재윤/성문희/김철중/Choi, Yoon Ho/Choi, Jae Yoon/Sung, Moon Hee/Kim, Chul Joong
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Abstract
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Genetically engineered bioproducts including anti-cancer drugs should be examined in the aspect of the efficacy and safety evaluation before the paractical use. In worldwide, efficacy evaluation could be done using the tumor cell lines with the advantage of easy evaluation of the results.
This study was carried out to investigate the antitumor activity of recombinant lymphotoxin (LT) ire vivo.
L929 cell line was implantated to BALES/C-nuKIST mouse and double dose of LT was given to intraperitoneally for 10 days.
After 6 weeks, LT treated group was clearly decreased tumor formation than non treated control group.
Non treated control group showed highly motality(80%) than LT treated group.
As a result LT had a antitumor activity that inhibited metastasis and growth.
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KEYWORD
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